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KMID : 0921620220520010020
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Journal of Bacteriology and Virology
2022 Volume.52 No. 1 p.20 ~ p.27
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Antiviral Activity of Quercetin-3-Glucoside Against Non-Polio Enterovirus
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Choi Hwa-Jung
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Abstract
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Non-polio enteroviruses (NPEVs) are primary causative agents of aseptic meningitis, encephalitis, hand, foot and mouth disease (HFMD), and myocarditis in infants and children and immunocompromised individuals. However, there are no approved treatments for NPEVs. It has been reported that flavonoids are abundantly found in plants and have antiviral activities. In this study, we explored the antiviral potential of quercetin-3-glucoside (Q3G), a natural flavonoid, against NPEVs such as coxsackievirus A16 and B3 (CVA16 and CVB3), enterovirus 71 (EV71), and human rhinovirus 1B (HRV 1B). Q3G showed potent antiviral activity against CVA16, CVB3, EV71, and HRV1B by suppressing the expression of viral RNA at the early stages of infection. Therefore, Q3G inhibits the early stages of the viral replication cycle and may provide an essential alternative for treating EV71, CVB3, CVA16, and HRV1B.
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KEYWORD
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Non-polio enteroviruses, Coxsackieviruses A16, Enterovirus 71, Coxsackieviruses B3, Human rhinovirus 1B, Quercetin-3-glucoside
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